The American surgeon
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The American surgeon · Oct 1994
Clinical TrialAppendiceal mass: conservative therapy followed by interval laparoscopic appendectomy.
Current therapy of patients with appendiceal abscess or phlegmon is in evolution. Controversial areas include initial conservative therapy, drainage of periappendiceal abscesses, and the role of interval appendectomy. ⋯ 1) Initial conservative management of patients with appendiceal abscess/phlegmon is prudent, safe, and effective. 2) Interval laparoscopic appendectomy can be performed safely and effectively.
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Amrinone is a noncatecholamine inotropic agent used clinically in the management of heart failure. The purpose of this study was to determine if intravenous (i.v.) infusion of amrinone has beneficial effects during resuscitation from experimental hemorrhagic shock. Effectiveness was defined as significantly improved survival rate. ⋯ Resuscitation in placebo (control) animals was with 54 ml/kg (2 times the hemorrhage volume) Lactated Ringer's solution over 1 hour, whereas resuscitation in drug-treated animals was with a 0.75 mg/kg bolus amrinone over 3 minutes followed by 54 ml/kg Lactated Ringer's solution and 5 ug/kg/min infusion over 1 hour. Results were that resuscitation with amrinone significantly increased MAP, tissue pO2, and survival over resuscitation with Lactated Ringer's alone (P < 0.05). In both trials, survival rates increased by more than 66 per cent in the amrinone groups.