Anaesthesia
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Comparative Study Clinical Trial Controlled Clinical Trial
Postoperative analgesia with ketamine and pethidine.
A double-blind trial compared ketamine with pethidine, pethidine alone at two dose levels and a placebo, in patients with postoperative pain. By assessment of pain intensity, observed relief and side-effects, the active drugs were clearly distinguishable from the placebo. With the doses used, however, the combination of ketamine with pethidine showed no advantage over pethidine alone.
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Case Reports
Toxic methaemoglobinaemia. A case of acute nitrobenzene and aniline poisoning treated by exchange transfusion.
A case of severe toxic methaemoglobinaemia following ingestion of aniline and nitrobenzene is described. Important factors in treatment are discussed. These include, gastric lavage, the administration of methylene blue and exchange transfusion. The possibility of a late haemolytic reaction being a complication of methylene blue treatment is mentioned.