Anaesthesia
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Edrophonium was administered as a bolus of 2, 10 or 50 mg (0.03, 0.14 and 0.71 mg/kg) to antagonize neuromuscular block after pancuronium in man. Neuromuscular transmission was measured using "train-of-four" stimulation. ⋯ The degree of recovery increased with larger doses of edrophonium and also was related to the total amount of pancuronium administered although reversal was attempted at the same degree of spontaneous recovery. There was no evidence of recurarisation or depolarising block.
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An accurate, simple and safe method, based upon cadaver studies, of obtaining a thoracic paravertebral block, suitable for repeated administration by catheter or for permanent accurate neurolytic block, and which carries significant advantages over intercostal or epidural block, is described in theory and practice.