Anaesthesia
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Comparative Study
Midazolam versus atropine plus pethidine as premedication in children.
The effects of oral midazolam or intramuscular atropine and pethidine used as premedication in two groups of 35 children over 5 years of age were studied. There was some evidence that the anxiolytic effect of midazolam was rather better than that of atropine plus pethidine, but, in other respects, subjective assessments in the two patient groups were similar. ⋯ Oral midazolam is a new anxiolytic drug which can be used as an alternative to existing premedicant drugs, but, in children, it should still be combined with an anticholinergic agent. No correlation between serum levels of midazolam or atropine and their clinical effects was found.
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The accuracy of the Dinamap 845 automatic blood pressure recorder was assessed by comparing its own indirect determinations of blood pressure with direct intra-arterial recordings. It was found that in the majority of cases it was capable of producing reliable trend information during anaesthesia. The instrument may not be able to interpret pressure signals from a patient with a severe dysrhythmia. It is probably an unsuitable monitor for use with very rapidly acting drugs such as sodium nitroprusside.
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In investigating the possible causes of an observed complication of intravenous regional anaesthesia, cubital fossa venous pressures were measured distal to an inflated tourniquet as standard 40 ml volumes of normal saline were injected. The maximal pressures obtainable were limited by tourniquet pressure since the veins compressed under the tourniquet acted as 'Starling' spillover resistors. ⋯ The rates of rise and maximum values of venous pressures tended to be increased by increased injection rates, and by failure to exsanguinate the arm, but the choice of injection site was paramount. Compared with more distal injections, cubital fossa venous injections are more likely to lead to leakage under the tourniquet and should never be used for intravenous regional anaesthesia.
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A case of glottic valvular obstruction following extubation is reported. The cause was bilateral dislocation of arytenoids due to coughing on the tracheal tube, which resolved automatically following a further bout of coughing.
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IgE levels were measured in 105 patients after immediate (101) and delayed (4) anaphylactoid reactions to anaesthetic drugs. It was not possible on the basis of allergic history and IgE levels in patients to determine the drugs to which the patients were likely to react. A history of allergy, atopy with or without elevated IgE levels, does not aid the selection of anaesthetic drugs for initial or repeat anaesthesia.