Anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Reducing the haemodynamic responses to laryngoscopy and intubation. A comparison of alfentanil with fentanyl.
The effects of alfentanil and fentanyl on controlling the haemodynamic responses to laryngoscopy and intubation have been compared. Five groups of ten patients were studied. Induction was with thiopentone 4 mg/kg. ⋯ In those given 15 and 30 micrograms/kg alfentanil it was 11 and 12 minutes respectively. In those given 5 micrograms/kg fentanyl it was greater than 15 minutes. Alfentanil is shown to reduce the cardiovascular responses to laryngoscopy and intubation and the effect appears to have a shorter duration than that of fentanyl.
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A case in which a mediastinal tumour caused complications including airway obstruction unrelieved by intubation during inhalational induction is described. Other case reports are reviewed and the anaesthetic management of patients with mediastinal tumours is discussed.