Anaesthesia
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The authors have examined early records of the administration of ether anaesthesia in Manchester and the lives of several medical men involved in these events. Charles Strange, a dentist and chemist, in a letter to the Manchester Guardian published on 14 January 1847, described a self-administration of ether for dental extraction, but George Bowring, a surgeon, subsequently claimed the first anaesthetic administered by a doctor in Manchester. The merits of these claims are discussed in the light of the circumstances surrounding these events.
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Randomized Controlled Trial Comparative Study Clinical Trial
A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia.
Thirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6 mg.kg-1 or vecuronium 0.1 mg.kg-1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train-of-four 70 were measured. ⋯ During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group.
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Randomized Controlled Trial Clinical Trial
Local anaesthetic: does it really reduce the pain of insertion of all sizes of venous cannula?
The pain of subcutaneous 1% lignocaine injection is significantly less than cannulation pain across all peripheral cannula sizes down to 22-gauge.
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