Anaesthesia
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Randomized Controlled Trial Clinical Trial
The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol.
We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient-controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml-1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml-1 in the morphine solution), or both drugs in combination. ⋯ There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient-controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery.
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Letter Case Reports
A case of intra-operative awareness during balanced anaesthesia with sufentanil.
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Letter Case Reports
Airway obstruction due to arytenoid prolapse in two children.
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Randomized Controlled Trial Clinical Trial
Lung aeration. The effect of pre-oxygenation and hyperoxygenation during total intravenous anaesthesia.
We have investigated the effect of pre-oxygenation and hyperoxygenation (an increase in inspired oxygen fraction from 0.4 to 1.0 after induction of general anaesthesia) on aeration and atelectasis formation in the lungs during total intravenous anaesthesia. Twenty-seven consecutive patients were randomly allocated to group 1 (with pre-oxygenation), group 2 (without pre-oxygenation), or group 3 (hyperoxygenation). Lung aeration was investigated by means of spiral computed tomography. ⋯ In group 1 larger areas of atelectasis were found in the basal parts of the lungs compared to group 2. In group 3 a significant increase in atelectatic areas with a corresponding reduction in areas with reduced aeration occurred at the bases of the lungs. The considerable increase in atelectasis associated with pre-oxygenation and its rapid appearance during hyperoxygenation suggest that these procedures should be used with caution.