Anaesthesia
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Randomized Controlled Trial Comparative Study
Epidural lidocaine-bicarbonate-adrenaline vs levobupivacaine for emergency Caesarean section: a randomised controlled trial.
Epidural mixtures containing lidocaine with or without additives are commonly used to convert epidural analgesia in labour to anaesthesia for emergency Caesarean section, but direct comparisons with alternative, single agents in this situation are few. In a prospective double-blinded trial, we compared a freshly prepared lidocaine-bicarbonate-adrenaline mixture (final concentrations 1.8%, 0.76% and 1:200,000, respectively) with our standard agent, levobupivacaine 0.5%, for extending epidural blockade for emergency Caesarean section. Using a sequential analysis technique, with data analysed in blocks of 40, women receiving epidural analgesia in labour who required top-up for Caesarean section were randomly assigned to receive 20 ml of epidural solution over 3 min. ⋯ Pre- and intra-operative supplementation/pain, maternal side-effects and neonatal outcomes (excluding five women who underwent instrumental delivery) were similar between the groups. Intra-operative maternal sedation (scored by the mother on a 10-point scale) was greater with lidocaine-bicarbonate-adrenaline (4.5 (3-8 [1-9])) than with levobupivacaine (3 (1-4 [1-7])), but not significantly so (p = 0.07). We conclude that epidural lidocaine-bicarbonate-adrenaline halves the onset time when extending epidural analgesia for Caesarean section although there is a possibility of increased maternal sedation.
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The noble gases have always been an enigma. Discovered late in the history of chemistry and in seemingly small quantities in our atmosphere, they are some of the most unreactive elements known. ⋯ Of all of them, the gases that have found the greatest number of uses in the field of anaesthesia and related specialties are helium and xenon. This review focuses on the history of the discovery of both gases, their unique physicochemical properties and describes their uses in clinical practice with particular emphasis on those applicable to anaesthesia.
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Multicenter Study
A national survey into the peri-operative anaesthetic management of patients presenting for surgical correction of a fractured neck of femur.
We conducted a national postal survey of trauma anaesthetists in the UK to ascertain current practice for the peri-operative anaesthetic management in patients with fractured necks of femur. We received 155 replies from 218 questionnaires sent (71.1% response rate). Regional anaesthesia was preferred by 75.8% of respondents, with 95.5% of these employing a spinal technique. ⋯ Continuous epidural or nerve block infusions were used rarely. Of the anaesthetists, 50.6% would only request a pre-operative echo if there were suspicious signs or symptoms in patients with a previously undiagnosed heart murmur. The peri-operative management of these patients can be readily improved.
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Hypoxaemia during anaesthetic induction in obstetrics is hazardous for mother and baby, but the onset of desaturation can be delayed by pre-oxygenation. This study investigated pre-oxygenation during pregnancy using computer simulation. The Nottingham Physiology Simulator was configured to replicate normal pregnant physiology. ⋯ Pre-oxygenation during tidal breathing proceeded more rapidly in pregnancy, the median [range] time to achieve 95% of the maximum change in P(E)O2 being 1 min 37 s [1:23-1:52] in pregnant subjects, compared to 2 min 51 s [2:28-3:15] in non-pregnant subjects. Vital capacity pre-oxygenation required seven breaths [5-10] in pregnant subjects, compared to six breaths [4-9] in non-pregnant subjects, to achieve the same P(E)O2 as after 95% complete tidal pre-oxygenation. We recommend 2 min of tidal breathing for pre-oxygenation in pregnancy.