Anaesthesia
The most recent articles from:
Anaesthesia
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Randomized Controlled Trial
A randomised controlled trial of dexmedetomidine for delirium in adults undergoing heart valve surgery.
Dexmedetomidine might reduce delirium after cardiac surgery. We allocated 326 participants to an infusion of dexmedetomidine at a rate of 0.6 μg kg-1 for 10 min and then at 0.4 μg.kg-1 .h-1 until the end of surgery; 326 control participants received comparable volumes of saline. ⋯ Postoperative renal impairment (Kidney Disease Improving Global Outcomes stages 1, 2 and 3) was detected in 46, 9 and 2 participants after dexmedetomidine and 25, 7 and 4 control participants, p = 0.040. Intra-operative dexmedetomidine infusion did not reduce the incidence of delirium after cardiac valve surgery but might impair renal function.