Transplant immunology
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Transplant immunology · Dec 2013
Multicenter Study Comparative Study Clinical TrialClinical relevance of pretransplant anti-HLA donor-specific antibodies: does C1q-fixation matter?
Anti-HLA donor-specific antibodies (DSA) identified by single antigen bead array (SAB) are questioned for their excess in sensitivity and lack of event prediction after transplantation. ⋯ C1q testing in pretransplant sera with DSA was unable to predict acute antibody-mediated rejection or early graft loss, but the presence of DSA class I compared to DSA only class II did. Despite non-fixing complement in vitro, pretransplant C1q-negative DSA I can mediate rejection and graft loss.