Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
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The intrasynovial flexor tendons of the hand are critical for normal hand function. Injury to these tendons can result in absent finger flexion, and a subsequent loss of overall hand function. ⋯ In spite of these advances, intrasynovial flexor tendon repairs continue to be plagued by postoperative scar formation, which limits tendon gliding and prevents a full functional recovery. This paper describes the current challenges of flexor tendon repair, and evaluates the most recent advances and strategies for achieving an excellent functional outcome.
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The effects upon skin repair were compared between a homemade bilayer dermal equivalent (BDE), composed of a collagen/chitosan porous scaffold and a silicone membrane, and J-1 acellular dermal matrix (ADM), a commercial ADM that is used widely in China to treat various skin defects. Full-thickness excisional and burn wounds were prepared on the backs of pigs and then treated with the BDE and J-1 ADM. Biopsy specimens were harvested on days 7, 14, and 21 after surgery for gross, biochemical, and molecular examinations. ⋯ However, there was a significant difference in the number of nascent blood vessels formed in the burn wounds after treatment with J-1 ADM compared with BDE. The highest numbers of newly formed and mature blood vessels were present in the J-1 ADM-treated excisional wounds after 21 days. Ultrathin skin grafts were further transplanted on to the regenerated dermis for 28 days, resulting in the repair of the full-thickness wounds and production of a structure similar to normal skin.