Ocular immunology and inflammation
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Ocul. Immunol. Inflamm. · Jan 2015
Intravitreal Dexamethasone Implant for Treatment of Refractory Behçet Posterior Uveitis: One-year Follow-up Results.
To investigate the results of dexamethasone (DEX) implant in the treatment of eyes with refractory Behçet posterior uveitis. ⋯ A single injection of DEX implant was safe and effective, as an additional treatment to systemic immunomodulatory drugs, in the treatment of refractory Behçet posterior uveitis, for a 6-month period.
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Ocul. Immunol. Inflamm. · Oct 2014
Case ReportsNeisseria meningitidis endogenous endophthalmitis with meningitis in an immunocompetent child.
Neisseria meningitidis is a major cause of childhood morbidity and mortality worldwide. We describe an exceptional case of an immunocompetent 15-month-old child presenting with a unilateral anterior uveitis, hypopyon, and sepsis. Anterior chamber aspirate demonstrated gram-negative cocci before Neisseria meningitidis was identified in blood and cerebrospinal fluid. ⋯ Simultaneous invasion of meningococcus across intact blood-brain and blood-ocular barriers in this child suggests antigenic correlates between meningeal and ocular endothelial interfaces. Meningococcus is an exclusively human pathogen; research is hampered by the lack of animal models. This clinical observation suggests the potential of a novel in vitro experimental approach of using ocular tissue from eye banks to further elucidate the meningococcal-endothelial interaction that underpins meningococcal disease.
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Ocul. Immunol. Inflamm. · Dec 2013
Long-term clinical outcomes in patients with refractory uveitis associated with Behçet disease treated with infliximab.
To assess long-term efficacy and safety of infliximab for refractory Behçet disease (BD) uveitis and to evaluate the effect of withdrawal of infliximab after achieving long-term remission. ⋯ Infliximab is effective and safe for long-term treatment for refractory BD uveitis. Repeated infusions are required to maintain long-term remission, which may be sustained despite withdrawal of infliximab. Induction of autoantibodies is common.
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Ocul. Immunol. Inflamm. · Oct 2013
Letter Case ReportsAssociation of bilateral acute anterior uveitis with a capsaicin patch.
To report a case of bilateral acute anterior uveitis in association with the application of an analgesic transdermal capsaicin patch. ⋯ The case suggests a possible association of capsaicin-containing transdermal patches and acute anterior uveitis.