Der Anaesthesist
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An intravenous infusion scheme was established in five healthy volunteers on the basis of pharmacokinetic analysis as described by J. G. Wagner. ⋯ An infusion model was developed for a therapeutic plasma concentration of 0.5 microgram/ml etomidate. An initial fast constant-rate infusion (8 mg/min) was followed by an infusion with 0.8 mg/min for the entire duration of the application. The measured plasma levels coincided fairly well with the predicted steady state plasma levels and were accompanied by a distinct hypnotic effect in all volunteers.
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Morphine 2 mg was injected directly into the intrathecal space in 33 patients. In the nonoperative group (group I) morphine was given with 2 ml saline solution; in the operative group (group II, 21 patients) morphine was given with 2 ml 10% glucose solution immediately before induction of anaesthesia. The onset of pain relief occurred after 12 to 35 min and the duration of analgesia was 14 and 18 35 min and the duration of analgesia was 14 and 48 hours. ⋯ In group I bladder insufficiency occurred in 2 cases. The disturbed bladder function recovered spontaneously in a few hours after morphine application. Respiratory depression was treated successfully with naloxone.
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We report on the development of a data collection form for anaesthesia. The difference between this form and the previously published recommendations is that it does not require any coding of data prior to collection. ⋯ Qualitative data have only to be marked, while quantitative data must be entered as such. So far, more than 90,000 anaesthesias have been collected with the form presented, therefore usefulness may be assumed.