Der Anaesthesist
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Randomized Controlled Trial Clinical Trial
[Ranitidine (Zantic) for aspiration prevention].
The new H2-receptor antagonists have been shown to be effective against the risk of gastric acid aspiration. The recommended dosage schedules, however, are not satisfactory in a clinical routine practice. Therefore the effect of the long acting agent ranitidine on pH and volume of gastric secretion after a single administration at 22.00 h on the previous evening has been investigated. ⋯ Ranitidine 150 mg and cimetidine 400 mg are not satisfactory, as expected. If an anaesthetic is scheduled to start later than 09.00, an additional dose of ranitidine should be administrated at 07.00. Ranitidine 300 mg provides an efficient prophylaxis against acid aspiration in one single dose and without additional medications at a time inconvenient for patient and nursing staff.
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Comparative Study
[Orciprenaline (Alupent) in resuscitation for circulatory arrest? Experimental comparison between orciprenaline and adrenaline in dogs].
This study compares CPR with orciprenaline (8 dogs), with epinephrine (11 dogs) and without any drug (8 dogs) in cardiac arrest caused by anoxia. Resuscitation was successful in all animals of the epinephrine group and in 2 of the orciprenaline group. Spontaneous circulation could not be restored in any of the control animals. ⋯ The superiority of epinephrine was due to its having effected a significantly higher diastolic pressure during cardiac massage. The diastolic pressure decreased after orciprenaline injection to such an extent that coronary underperfusion resulted with consequent rise of serum CPK. We conclude that the use of orciprenaline is contraindicated in cardiac arrest.