Current opinion in neurology
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Curr. Opin. Neurol. · Jun 1995
ReviewAcute disseminated encephalomyelitis and isolated central nervous system demyelinative syndromes.
The clinical and pathological characteristics of acute disseminated encephalomyelitis are briefly outlined. The possible relation between acute disseminated encephalomyelitis and other isolated monophasic inflammatory demyelinating episodes in the central nervous system, such as acute optic neuritis, transverse myelitis or brainstem lesions, is noted and the risk of progression to multiple sclerosis is examined. ⋯ Finally, the risk factors for the progression of demyelinating ther than optic neuritis to multiple sclerosis are explored. Further work to elucidate better the relationships between these pathological entities is suggested.
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A review of the literature dealing with patients presenting with headache caused by underlying disease reinforces the classic teaching that these headaches are hardly ever completely typical of benign syndromes such as migraine. More often than not they are accompanied by features, such as other symptoms or physical abnormalities, that suggest, to the careful clinician, the suspicion of a lesion and the need for investigation.