Current opinion in neurology
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Curr. Opin. Neurol. · Jun 2005
ReviewPatent foramen ovale: paradoxical connection to migraine and stroke.
In this article we aim to elucidate the relationship between patent foramen ovale, cryptogenic stroke and migraine. ⋯ At present routine percutaneous closure of isolated patent foramen ovale cannot be recommended for patients with cryptogenic stroke. Patent foramen ovale closure should not be used for the prevention of migraine.
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Curr. Opin. Neurol. · Jun 2005
ReviewGenomics, proteomics, metabolomics: what is in a word for multiple sclerosis?
Multiple sclerosis (MS) is the most common chronic inflammatory neurological disease. Despite major advances the aetiology of this disease it is still not completely understood. In the post-genome era, advances in global screening technologies offer an opportunity to accelerate the search of new pathological pathways and to identify new therapeutic targets. Some recent publications using novel global screening methods at the genome, transcriptome, proteome and metabolome levels are discussed. ⋯ The complexity of MS is clearly reflected in the latest findings using global profiling methods. Nevertheless, these new technologies are confirming some of the basic aspects of the disease pathophysiology, i.e. its polygenicity, the central role of neuroinflammation and the emerging neurodegenerative processes. These data are primarily the results of genomic approaches, yet promising attempts are also made using proteomics and metabolomics.