Current opinion in neurology
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Recent neuroimaging studies have provided novel insights on residual brain function in patients with disorders of consciousness, but also raised a number of ethical issues concerning the clinical management of these patients. ⋯ There is an urgent need of validation of functional MRI active paradigms on larger patient populations before they can be used in clinical routine. Further research on neural correlates of consciousness should hopefully allow using passive paradigms to assess the patients' conscious state without requiring their active collaboration.
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This review enumerates recent developments in the early diagnosis of Parkinson's disease, with an emphasis on detection of preclinical Parkinson's disease. ⋯ Various diagnostic modalities hold promise for the early and preclinical diagnosis of Parkinson's disease. It is likely that the future diagnosis of Parkinson's disease will rely on a combination of clinical, laboratory, imaging, and genetic data.