Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
Infiltration pain and local anesthetic effects of buffered vs plain 1% diphenhydramine.
To compare the levels of infiltration pain and local anesthetic effects of plain and buffered 1% diphenhydramine. ⋯ In a study with a sample size large enough to detect an 11-mm difference in VAS scores (power = 80%), no difference was found in pain of infiltration and anesthetic effects when plain 1% diphenhydramine was compared with buffered 1% diphenhydramine. Buffering of diphenhydramine does not appear to result in a clinically significant reduction in the pain of infiltration.