Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
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To evaluate the effect of amrinone as a treatment for the hemodynamic effects of verapamil overdose in a canine model. ⋯ Amrinone appears to reverse the depressed cardiac index associated with verapamil overdose in a canine model while having no significant effect on the hypotension or bradycardia.
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Randomized Controlled Trial Comparative Study Clinical Trial
A pharmacokinetic comparison of acetaminophen products (Tylenol Extended Relief vs regular Tylenol)
To compare the pharmacokinetics of Tylenol Extended Relief (ER APAP) with those of immediate-release acetaminophen (IR APAP) at supratherapeutic doses. ⋯ In this model involving a single supratherapeutic dose, ER APAP evidenced no pharmacokinetic features that would suggest the need for an alternate poisoning screening strategy. When compared with IR APAP, ER APAP had a lower AUC, all peak [APAP] occurred in < 4 hours, and terminal eliminations were identical. The data suggest that, in most cases, the diagnostic approach to an overdose of ER APAP need not deviate from that used for an IR APAP overdose.
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To examine the concordance of pediatric radiograph interpretation between emergency medicine residents (EMRs) and radiologists. ⋯ 89.4% of all the radiographs interpreted by PGY1-3 residents were read correctly. Only 1.69% of the misinterpreted radiographs led to a change in management. Level of training did not significantly correlate with radiograph misinterpretation rates.
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Case Reports
Blood cultures in adult patients released from an urban emergency department: a 15-month experience.
To determine the frequency of positive blood cultures obtained from adult patients with potential occult bacteremia released from an urban ED and how often these positive cultures alter the subsequent patient course or management. ⋯ The prevalence of bacteremia was 1.8% among the released patients who had blood cultures obtained in the ED. Furthermore, only 0.52% of the patients had positive blood cultures that potentially affected their medical management. Further study is warranted to identify specific criteria for selecting ambulatory patients for whom the use of blood cultures may be cost-effective.
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To evaluate a bioimpedance device for the noninvasive measurement of cardiac index (CI) against standard thermodilution measurements in patients with gunshot wounds. ⋯ Cardiac index can be noninvasively estimated in acutely injured patients with gunshot wounds using a bioimpedance device. Further study of bioimpedance measurements as a guide to volume therapy is warranted.