Human brain mapping
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Human brain mapping · Aug 2013
Altered resting-state connectivity during interictal generalized spike-wave discharges in drug-naïve childhood absence epilepsy.
To investigate the intrinsic brain connections at the time of interictal generalized spike-wave discharges (GSWDs) to understand their mechanism of effect on brain function in untreated childhood absence epilepsy (CAE). ⋯ The current findings demonstrate significant alterations of resting-state networks in drug naïve CAE subjects during interictal GSWDs and interictal GSWDs can cause dysfunction in specific networks important for psychosocial function. Impairment of these networks may cause deficits both during and between seizures. Our study may contribute to the understanding of neuro-pathophysiological mechanism of psychosocial function impairments in patients with CAE.