Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
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The efficacy of single daily dose of amikacin has been recently demonstrated in neutropenic children with fever. ⋯ The use of single daily dose amikacin in combination with a broad spectrum beta-lactam antibiotic and vancomycin was efficient and safe in febrile granulocytopenic children. The simulation of the amikacin behaviour in the deep compartment should be evaluated; in fact, it might reflect better accumulation of the drug than serum concentrations.
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Polycythemia vera is a very rare disease in childhood; its treatment for this reason is not well established. ⋯ Oral continuous myelosuppressive therapy with hydroxyurea may be proposed in children if there is no HLA-matched family member. Long-term follow-up is nevertheless necessary in order to detect relapse or side-effects of the treatment.