Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
-
Case Reports
[Analgesic efficacy of topical lidocaine for vaso-occlusive crisis in children with sickle cell disease].
Pain associated with vaso-occlusive crisis is the main cause of hospitalization in children with sickle cell disease. Recent studies have suggested that pain might have a neuropathic component. ⋯ This study reports the efficacy and safety of such treatment in 6 patients with sickle cell disease, aged 6-18 years, who had been hospitalized for vaso-occlusive crisis after failure of the standard analgesic treatment. These data have led to setting up a confirmatory phase II trial, which is currently underway.