Drug metabolism and disposition : the biological fate of chemicals
The most recent articles from:
January 2013
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Drug Metab. Dispos. · Jan 2013
Clinical TrialEffects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients.
Therapeutic hypothermia (TH) may induce pharmacokinetic changes that may affect the level of sedation. We have compared the disposition of morphine, midazolam, fentanyl, and propofol in TH with normothermia in man. Fourteen patients treated with TH following cardiac arrest (33-34°C) were compared with eight matched critically ill patients (36-38°C). ⋯ Compared with the matched, normothermic intensive care unit patients, t(1/2) of morphine was significantly higher during TH. CL(tot) was lower during TH for morphine, fentanyl, and propofol but not for midazolam. Reducing the infusion rates of morphine, fentanyl, and propofol during TH is encouraged.