Shock : molecular, cellular, and systemic pathobiological aspects and therapeutic approaches : the official journal the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies
-
A Physiologic State Severity Classification (PSSC) derived from clustering of 17 cardiorespiratory variables was used to predict cytokine response in critically ill posttrauma patients. The PSSC defined physiologic states: A-State (A), normal stress response; B-State (B), metabolic insufficiency; C2-State (C), respiratory insufficiency. ⋯ Of 25 deaths (88% s, 60% s-ARDS, mean Pdeath = .64) 0% were A, 44% B, and 56% C. PSSC States were correlated with incidence and mean plasma levels (pl) in picograms/mL of cytokines. 23 samples from recovering nonseptic trauma patients were used as controls.
-
Hypertonic sodium acetate has recently been suggested for treatment of hemorrhagic shock. In the present study, the effectiveness of hypertonic sodium acetate (HA) was studied. In controlled hemorrhagic shock, arterial bleeding was followed by a fall in mean arterial pressure (MAP) to 60 +/- 8 mmHg (p < .001). ⋯ The mortality rate after 4 h was 50% in the HA-treated (p < .05) and 75% in the HTS-treated (p < .01) groups. It is concluded that, in awake rats in CHS, both HTS and HA led to a rise in MAP but the response to HTS is significantly higher. In UCHS both HTS and HA led to increased bleeding from injured blood vessels, a fall in MAP, and increased mortality.