American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2011
Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.
Exudate macrophages are key players in host defense toward invading pathogens. Their antiinflammatory and epithelial-protective potential in gram-negative pneumonia, however, remains elusive. ⋯ We conclude that recruited lung macrophages attenuate IL-1β-mediated acute lung injury in gram-negative pneumonia by release of IL-1ra.
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Am. J. Respir. Crit. Care Med. · May 2011
Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment.
Obstructive sleep apnea (OSA) is commonly associated with neurocognitive impairments that have not been consistently related to specific brain structure abnormalities. Knowledge of the brain structures involved in OSA and the corresponding functional implications could provide clues to the pathogenesis of cognitive impairment and its reversibility in this disorder. ⋯ The cognitive and structural deficits in OSA may be secondary to sleep deprivation and repetitive nocturnal intermittent hypoxemia. These negative effects may be recovered by consistent and thorough treatment. Our findings highlight the importance of early diagnosis and successful treatment of this disorder.