American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2011
Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A.
IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. ⋯ IL-22 is required for the onset of allergic asthma, but functions as a negative regulator of established allergic inflammation. Our study reveals that IL-22 contributes to the proinflammatory properties of IL-17A in experimental allergic asthma.
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Am. J. Respir. Crit. Care Med. · May 2011
Treatment of tuberculosis with rifamycin-containing regimens in immune-deficient mice.
Daily rifapentine plus isoniazid-pyrazinamide in mice infected with Mycobacterium tuberculosis produces cure in 3 months. Whether cure corresponds to latent infection contained by host immunity or true tissue sterilization is unknown. ⋯ In nude mice, sterilization of tuberculosis is obtained with rifapentine-containing treatment, whereas failure with development of isoniazid resistance is obtained with rifampin-containing treatment.