American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2011
Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm ozone for 6.6 hours.
Exposure to ozone causes a decrease in spirometric lung function and an increase in airway inflammation in healthy young adults at concentrations as low as 0.08 ppm, close to the National Ambient Air Quality Standard for ground level ozone. ⋯ Exposure of healthy young adults to 0.06 ppm ozone for 6.6 hours causes a significant decrement of FEV(1) and an increase in neutrophilic inflammation in the airways. GSTM1 genotype alone appears to have no significant role in modifying the effects.
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Am. J. Respir. Crit. Care Med. · May 2011
Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A.
IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. ⋯ IL-22 is required for the onset of allergic asthma, but functions as a negative regulator of established allergic inflammation. Our study reveals that IL-22 contributes to the proinflammatory properties of IL-17A in experimental allergic asthma.