American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2012
Randomized Controlled Trial Multicenter Study Comparative StudyLong-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study.
New treatment strategies are needed to improve airway clearance and reduce the morbidity and the time burden associated with cystic fibrosis (CF). ⋯ Inhaled mannitol, 400 mg twice a day, resulted in improved lung function over 26 weeks, which was sustained after an additional 26 weeks of treatment. The safety profile was also acceptable, demonstrating the potential role for this chronic therapy for CF. Clinical trial registered with www.clinicaltrials.gov (NCT 00630812).
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Am. J. Respir. Crit. Care Med. · Mar 2012
Comparative StudyA comparison between two strategies for monitoring hepatic function during antituberculous therapy.
The optimum strategy for monitoring liver function during antituberculous therapy is unclear. ⋯ In our urban, ethnically diverse population, a risk-factor approach is neither sensitive nor specific for prediction of drug-induced liver injury. A uniform policy of liver function testing at 2 weeks is useful for prompt identification of a subgroup who develop early drug-induced liver injury and may offer better specificity in ruling out late drug-induced liver injury.