American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2012
Comparative StudyThe clinical and environmental determinants of airway transcriptional profiles in allergic asthma.
Gene expression profiling of airway epithelial and inflammatory cells can be used to identify genes involved in environmental asthma. ⋯ Our results indicate that among individuals with allergic asthma, transcriptional changes in airway epithelia and inflammatory cells are influenced by phenotype as well as environmental exposures.
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Am. J. Respir. Crit. Care Med. · Mar 2012
Comparative StudyDisruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.
Acute lung injury (ALI) causes high mortality, but its molecular mechanisms and therapeutic options remain ill-defined. Gram-negative bacterial infections are the main cause of ALI, leading to lung neutrophil infiltration, permeability increases, deterioration of gas exchange, and lung damage. Platelets are activated during ALI, but insights into their mechanistic contribution to neutrophil accumulation in the lung are elusive. ⋯ Taken together, our data identify a novel function of platelet-derived chemokine heteromers during ALI and demonstrate means for therapeutic interference.