American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2014
Multicenter StudyEffects of a Functional Variant c.353T>C in Snai1 on Risk of Two Contextual Diseases: COPD and Lung Cancer.
Epithelial-mesenchymal transition (EMT) plays a key role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer. ⋯ The functional germline variant c.353T>C (p.Val118Ala) of Snai1 confers consistently decreased risks of lung cancer and COPD, and this variant affects lung cancer risk through a mediation effect of COPD.
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Am. J. Respir. Crit. Care Med. · Jan 2014
Risk for Tuberculosis in Child Contacts: Development and Validation of a Predictive Score.
Contact investigation of persons exposed to tuberculosis (TB) is resource intensive. To date, no clinical prediction rule for TB risk exists for use as a guide during contact investigation. ⋯ A risk predictive score was developed and validated to identify child contacts aged 0 to 12 years at increased risk for active TB. This predictive score can help to prioritize active case finding or isoniazid preventive therapy among children exposed to TB.