American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2014
Randomized Controlled Trial Multicenter StudyThe Beta Agonist Lung Injury Trial (BALTI) Prevention: A Randomized Controlled Trial.
Experimental studies suggest that pretreatment with β-agonists might prevent acute lung injury (ALI). ⋯ Perioperative treatment with inhaled salmeterol was well tolerated but did not prevent ALI. Clinical trial registered with International Standard Randomized Controlled Trial Register (ISRCTN47481946) and European Union database of randomized Controlled Trials (EudraCT 2007-004096-19).
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Am. J. Respir. Crit. Care Med. · Mar 2014
Clinical TrialQuantification of Pulmonary Inflammation after Segmental Allergen Challenge Using TIRM Magnetic Resonance Imaging.
There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. ⋯ The MRI-based noninvasive TIRM score is a promising biomarker for the noninvasive detection of the inflammatory response after segmental allergen challenge in patients with asthma and may serve to monitor the therapeutic effectiveness of novel antiinflammatory drugs in future human trials.