American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2014
Comparative StudyComparison of Viral Load in Individuals with and without Asthma During Infections with Rhinovirus.
Most virus-induced attacks of asthma are caused by rhinoviruses (RVs). ⋯ During acute symptoms, children infected with RV enrolled for wheezing or acute rhinitis had similar viral loads in their nasal washes, as did adults with and without asthma infected with RV-16 experimentally.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Comparative Study Clinical TrialLung Clearance Index is a Repeatable and Sensitive Indicator of Radiological Changes in Bronchiectasis.
In bronchiectasis there is a need for improved markers of lung function to determine disease severity and response to therapy. ⋯ The lung clearance index is repeatable and a more sensitive measure than FEV1 in the detection of abnormalities demonstrated on CT scan. The lung clearance index has the potential to be a useful clinical and research tool in patients with bronchiectasis.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea.
An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth and metastasis in mice. ⋯ Our findings support the notion that IH-induced alterations in TAMs participate in the adverse cancer outcomes reported in OSA.