American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2014
Comparative Study Clinical TrialLung Clearance Index is a Repeatable and Sensitive Indicator of Radiological Changes in Bronchiectasis.
In bronchiectasis there is a need for improved markers of lung function to determine disease severity and response to therapy. ⋯ The lung clearance index is repeatable and a more sensitive measure than FEV1 in the detection of abnormalities demonstrated on CT scan. The lung clearance index has the potential to be a useful clinical and research tool in patients with bronchiectasis.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Hospital Case Volume and Outcomes among Patients Hospitalized with Severe Sepsis.
Processes of care are potential determinants of outcomes in patients with severe sepsis. Whether hospitals with more experience caring for patients with severe sepsis also have improved outcomes is unclear. ⋯ Academic hospitals with higher severe sepsis case volume have lower severe sepsis hospital mortality without higher costs.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Comparative StudyComparison of Viral Load in Individuals with and without Asthma During Infections with Rhinovirus.
Most virus-induced attacks of asthma are caused by rhinoviruses (RVs). ⋯ During acute symptoms, children infected with RV enrolled for wheezing or acute rhinitis had similar viral loads in their nasal washes, as did adults with and without asthma infected with RV-16 experimentally.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Patent foramen ovale is not associated with hypoxemia in severe COPD and does not impair exercise performance.
Patent foramen ovale (PFO) may be disadvantageous in chronic obstructive pulmonary disease (COPD). It is unknown whether right-to-left shunting through PFO increases during exercise impairing exercise performance. ⋯ Hypoxemic patients with COPD do not have a higher prevalence of PFO. Patients with COPD with PFO do not perform less well either on a 6-minute walk or submaximal exercise testing despite increased right-to-left shunting during exercise.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea.
An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth and metastasis in mice. ⋯ Our findings support the notion that IH-induced alterations in TAMs participate in the adverse cancer outcomes reported in OSA.