American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Apr 2014
Comparative StudyCCL17 Production by Dendritic Cells is Required for NOD1-mediated Exacerbation of Allergic Asthma.
Pattern recognition receptors are attractive targets for vaccine adjuvants, and polymorphisms of the innate receptor NOD1 have been associated with allergic asthma. ⋯ Data from this study unveil a deleterious role of NOD1 in allergic asthma through direct induction of CCL17 by dendritic cells, arguing for a need to address vaccine formulation safety issues related to allergy.