American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Aug 2014
Is Chronic Asthma Associated with Shorter Leukocyte Telomere Length at Midlife?
Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. ⋯ Life-course-persistent asthma is related to a proposed biomarker of accelerated aging, possibly via systemic eosinophilic inflammation. Life histories of asthma can inform studies of aging.
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Am. J. Respir. Crit. Care Med. · Aug 2014
Integrative 'Omic Analysis of Experimental Bacteremia Identifies a Metabolic Signature that Distinguishes Human Sepsis from SIRS.
Sepsis is a leading cause of morbidity and mortality. Currently, early diagnosis and the progression of the disease are difficult to make. The integration of metabolomic and transcriptomic data in a primate model of sepsis may provide a novel molecular signature of clinical sepsis. ⋯ A model of sepsis based on reciprocal metabolomic and transcriptomic data was developed in primates and validated in two human patient cohorts. It is anticipated that the identified parameters will facilitate early diagnosis and management of sepsis.
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Am. J. Respir. Crit. Care Med. · Aug 2014
A Functional Anatomic Defect of the Cystic Fibrosis Airway.
The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. ⋯ An inherent defect in CF airway surface liquid contributes to delayed MCT beyond that caused by airway dehydration alone and identifies a fundamental mechanism underlying the pathogenesis of CF lung disease in the absence of antecedent infection or inflammation.