American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Aug 2014
Randomized Controlled Trial Clinical TrialAcute outcomes and 1-year mortality of ICU-acquired weakness: A cohort study and propensity matched analysis.
Intensive care unit (ICU)-acquired weakness is a frequent complication of critical illness. It is unclear whether it is a marker or mediator of poor outcomes. ⋯ After careful matching the data suggest that ICU-acquired weakness worsens acute morbidity and increases healthcare-related costs and 1-year mortality. Persistence and severity of weakness at ICU discharge further increased 1-year mortality. Clinical trial registered with www.clinicaltrials.gov (NCT 00512122).
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Am. J. Respir. Crit. Care Med. · Aug 2014
Randomized Controlled TrialNasal High-flow vs Venturi Mask Oxygen Therapy After Extubation: Effects on Oxygenation, Comfort and Clinical Outcome.
Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. ⋯ Compared with the Venturi mask, NHF results in better oxygenation for the same set FiO2 after extubation. Use of NHF is associated with better comfort, fewer desaturations and interface displacements, and a lower reintubation rate. Clinical trial registered with www.clinicaltrials.gov (NCT 01575353).
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Am. J. Respir. Crit. Care Med. · Aug 2014
Randomized Controlled Trial Observational StudyThe Impact of Breastfeeding on Nasopharyngeal Microbial Communities in Infants.
Breastfeeding elicits significant protection against respiratory tract infections in infancy. Modulation of respiratory microbiota might be part of the natural mechanisms of protection against respiratory diseases induced by breastfeeding. ⋯ Our data suggest a strong association between breastfeeding and microbial community composition in the upper respiratory tract of 6-week-old infants. Observed differences in microbial community profile may contribute to the protective effect of breastfeeding on respiratory infections and wheezing in early infancy. Clinical trial registered with www.clinicaltrials.gov (NCT 00189020).