American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Jan 2015
New Risk Factors for Adult Onset Incident Asthma: A Nested Case Control Study of Host Antioxidant Defense.
Host antioxidant defense, consisting of enzymatic antioxidant activity and nonenzymatic antioxidant micronutrients, is implicated in asthma pathogenesis. Studies of antioxidant defense and adult incident asthma have either used measures of antioxidants estimated from questionnaires or not considered enzymatic aspects of host defense. ⋯ In this prospective study, α-tocopherol, within normal reference ranges, and PAF-AH enzymatic activity were associated with decreased asthma development. These modifiable risk factors may be an effective strategy to test for primary asthma prevention.
-
Am. J. Respir. Crit. Care Med. · Jan 2015
Clinical TrialIntermittent Antibiotic Therapy for Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease.
Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. ⋯ These results suggest that intermittent three-times-weekly therapy with a macrolide, rifampin, and ethambutol is a reasonable initial treatment regimen for patients with noncavitary nodular bronchiectatic MAC lung disease. Clinical trial registered with www.clinicaltrials.gov (NCT 00970801).
-
Am. J. Respir. Crit. Care Med. · Jan 2015
Comparative StudyDisparities in Pulmonary Function in Healthy Children Across the Indian Urban-Rural Continuum.
Marked socioeconomic health-care disparities are recognized in India, but lung health inequalities between urban and rural children have not been studied. ⋯ The presence of an urban-rural continuum of lung function within a specific ethnic group emphasizes the impact of environmental factors on lung growth in emerging nations such as India, which must be taken into account when developing ethnic-specific reference values or designing studies to optimize lung health.