American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2015
Observational StudyFailure of Empirical Systemic Antifungal Therapy in Mechanically-ventilated Critically Ill Patients.
Systemic antifungal treatments are empirically administered to the sickest critically ill patients, often without documented invasive fungal infection. ⋯ This study failed to show outcome benefits for empirical systemic antifungal therapy in the sickest critically ill, nonneutropenic, nontransplanted patients. The post hoc power did not allow us to conclude to an absence of treatment effect especially for specific subgroups. Studies to refine indications for empirical treatment based on surrogate markers of invasive candidiasis are warranted.