American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2015
Letter Case Reports Randomized Controlled TrialLow-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.
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Am. J. Respir. Crit. Care Med. · Jul 2015
Practice GuidelineAn Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline.
This document updates the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association guideline on idiopathic pulmonary fibrosis treatment. ⋯ The panel formulated and provided the rationale for recommendations in favor of or against treatment interventions for idiopathic pulmonary fibrosis.
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Am. J. Respir. Crit. Care Med. · Jul 2015
Airway Remodeling in Preschool Children with Severe Recurrent Wheeze.
Airway wall structure in preschoolers with severe recurrent wheeze is poorly described. ⋯ In preschoolers with severe recurrent wheeze, markers of remodeling and inflammation are unrelated, and atopy is associated with ASM. In the absence of control subjects, we cannot determine whether differences observed in RBM thickness and vascularity result from disease or normal age-related development.
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Am. J. Respir. Crit. Care Med. · Jul 2015
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.
Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. ⋯ Abnormal regulation of airway surface hydration may slow MCC in CB and contribute to disease pathogenesis.
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Am. J. Respir. Crit. Care Med. · Jul 2015
Soluble RAGE Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.
Levels of the soluble form of the receptor for advanced glycation end-products (sRAGE) are elevated during acute respiratory distress syndrome (ARDS) and correlate with severity and prognosis. Alveolar fluid clearance (AFC) is necessary for the resolution of lung edema but is impaired in most patients with ARDS. No reliable marker of this process has been investigated to date. ⋯ Our results indicate that sRAGE levels could be a reliable predictor of impaired AFC during ARDS, and should stimulate further studies on the pathophysiologic implications of RAGE axis in the mechanisms leading to edema resolution. Clinical trial registered with www.clinicaltrials.gov (NCT 00811629).