American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2016
Randomized Controlled TrialBlood Pressure Response to Losartan and CPAP in Hypertension and Obstructive Sleep Apnea.
Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. ⋯ Losartan reduced BP in OSA, but the reductions were less than in no-OSA. Add-on CPAP therapy resulted in no significant changes in 24-hour BP measures except in patients using CPAP efficiently. Clinical trial registered with www.clinicaltrials.gov (NCT00701428).
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Am. J. Respir. Crit. Care Med. · Feb 2016
Randomized Controlled Trial Comparative StudyThe Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock.
Septic shock is a common cause of acute kidney injury (AKI), and fluid resuscitation is a major part of therapy. ⋯ In patients with septic shock, AKI is common and associated with adverse outcomes, but it is not influenced by protocolized resuscitation compared with usual care.
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Am. J. Respir. Crit. Care Med. · Feb 2016
Randomized Controlled TrialRandomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill.
Hypoxemia is common during endotracheal intubation of critically ill patients and may predispose to cardiac arrest and death. Administration of supplemental oxygen during laryngoscopy (apneic oxygenation) may prevent hypoxemia. ⋯ Apneic oxygenation does not seem to increase lowest arterial oxygen saturation during endotracheal intubation of critically ill patients compared with usual care. These findings do not support routine use of apneic oxygenation during endotracheal intubation of critically ill adults. Clinical trial registered with www.clinicaltrials.gov (NCT 02051816).