American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2016
Multicenter StudyMulticenter Implementation of a Treatment Bundle for Sepsis Patients with Intermediate Lactate Values.
Treatments for patients with sepsis with intermediate lactate values (≥2 and <4 mmol/L) are poorly defined. ⋯ Multicenter implementation of a treatment bundle for patients with sepsis and intermediate lactate values improved bundle compliance and was associated with decreased hospital mortality. These decreases were mediated by improved mortality and increased fluid administration among patients with a history of heart failure and/or chronic kidney disease.