American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2016
Randomized Controlled TrialThe Effects of LAIV on Nasopharyngeal Bacteria in Healthy 2-4 Year Olds: a Randomized Controlled Trial.
Viral infections of the upper respiratory tract may influence the commensal nasopharyngeal bacteria. Changes in the bacterial niche could affect transmission dynamics. Attenuated vaccine viruses can be used to investigate this empirically in humans. ⋯ In the absence of any safety signals despite widespread use of the vaccine, these findings suggest that bacterial density, and thus transmission rates among children and to people in other age groups, may rise following attenuated influenza infections without associated clinical disease. LAIV could therefore be used as an experimental tool to elucidate the dynamics of transmission of nasopharyngeal bacteria.