American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Dec 2017
Letter Randomized Controlled TrialTriplicate Sputum Cultures for Efficacy Evaluation of Novel Anti-tuberculosis Regimens.
-
Am. J. Respir. Crit. Care Med. · Dec 2017
Randomized Controlled Trial Multicenter StudyA Multicenter RCT of Zephyr® Endobronchial Valve Treatment in Heterogeneous Emphysema (TRANSFORM).
Single-center randomized controlled trials of the Zephyr endobronchial valve (EBV) treatment have demonstrated benefit in severe heterogeneous emphysema. This is the first multicenter study evaluating this treatment approach. ⋯ EBV treatment in hyperinflated patients with heterogeneous emphysema without collateral ventilation resulted in clinically meaningful benefits in lung function, dyspnea, exercise tolerance, and quality of life, with an acceptable safety profile. Clinical trial registered with www.clinicaltrials.gov (NCT02022683).