American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2017
S1PR3 Signaling Drives Bactericidal Killing and is Required for Survival in Bacterial Sepsis.
Efficient elimination of pathogenic bacteria is a critical determinant in the outcome of sepsis. Sphingosine-1-phosphate receptor 3 (S1PR3) mediates multiple aspects of the inflammatory response during sepsis, but whether S1PR3 signaling is necessary for eliminating the invading pathogens remains unknown. ⋯ S1PR3 signaling drives bacterial killing and is essential for survival in bacterial sepsis. Interventions targeting S1PR3 signaling could have translational implications for manipulating the innate immune response to combat pathogens.