American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2017
Practice GuidelineRecommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement.
The American Thoracic Society committee on Proficiency Standards for Pulmonary Function Laboratories has recognized the need for a standardized reporting format for pulmonary function tests. Although prior documents have offered guidance on the reporting of test data, there is considerable variability in how these results are presented to end users, leading to potential confusion and miscommunication. ⋯ The committee believes that wide adoption of these formats and their underlying principles by equipment manufacturers and pulmonary function laboratories can improve the interpretation, communication, and understanding of test results.
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Am. J. Respir. Crit. Care Med. · Dec 2017
Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype in Asthma.
Mepolizumab, an IL-5-blocking antibody, reduces exacerbations in patients with severe eosinophilic asthma. Mepolizumab arrests eosinophil maturation; however, the functional phenotype of eosinophils that persist in the blood and airway after administration of IL-5 neutralizing antibodies has not been reported. ⋯ Mepolizumab reduced airway eosinophil numbers but had a limited effect on airway eosinophil activation markers, suggesting that these cells retain functionality. This observation may explain why IL-5 neutralization reduces but does not completely eradicate asthma exacerbations. Clinical trial registered with www.clinicaltrials.gov (NCT00802438).
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Am. J. Respir. Crit. Care Med. · Dec 2017
Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis.
Vascular endothelial growth factor down-regulates microRNA-1 (miR-1) in the lung endothelium, and endothelial cells play a critical role in tumor progression and angiogenesis. ⋯ Endothelial miR-1 is down-regulated in NSCLC tumors and controls tumor progression and angiogenesis.