American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2017
A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED.
Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. ⋯ This analysis demonstrates the usefulness of a transcriptomics-driven approach to phenotyping that segments patients who may benefit the most from specific agents that target T-helper cell type 2-mediated inflammation and/or corticosteroid insensitivity.
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Am. J. Respir. Crit. Care Med. · Feb 2017
Multicenter Study Clinical TrialBiomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.
Chronic obstructive pulmonary disease exacerbations are associated with disease progression, higher healthcare cost, and increased mortality. Published predictors of future exacerbations include previous exacerbation, airflow obstruction, poor overall health, home oxygen use, and gastroesophageal reflux. ⋯ Blood biomarkers were significantly associated with the occurrence of exacerbations but were not robust between cohorts and added little to the predictive value of clinical covariates for exacerbations.