American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2017
miR-138 and miR-25 Downregulate MCU, Causing Pulmonary Arterial Hypertension's Cancer Phenotype.
Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and apoptosis resistance. This cancer-like phenotype is promoted by increased cytosolic calcium ([Ca2+]cyto), aerobic glycolysis, and mitochondrial fission. ⋯ These results highlight miR-mediated MCUC dysfunction as a unifying mechanism in PAH that can be therapeutically targeted.