American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2017
Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis.
Sputum neutrophil elastase and serum desmosine, which is a linked marker of endogenous elastin degradation, are possible biomarkers of disease severity and progression in bronchiectasis. This study aimed to determine the association of elastase activity and desmosine with exacerbations and lung function decline in bronchiectasis. ⋯ Sputum neutrophil elastase activity is a biomarker of disease severity and future risk in adults with bronchiectasis.