American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2017
Randomized Controlled TrialImpact of Mandibular Advancement Therapy on Endothelial Function in Severe Obstructive Sleep Apnea.
Endothelial dysfunction, a major predictor of late cardiovascular events, is linked to the severity of obstructive sleep apnea (OSA). ⋯ In moderately sleepy patients with severe OSA, mandibular advancement therapy reduced OSA severity and related symptoms but had no effect on endothelial function and blood pressure despite high treatment compliance. Clinical trial registered with www.clinicaltrials.gov (NCT 01426607).