American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2017
Anti-histone Properties of C1 Esterase Inhibitor Protect Against Lung Injury.
Acute respiratory distress syndrome is characterized by alveolar epithelial cell injury, edema formation, and intraalveolar contact phase activation. ⋯ Collectively, C1INH administration provides a new therapeutic option for disorders associated with histone release.
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Am. J. Respir. Crit. Care Med. · Jul 2017
Microbes Associate with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.
Differences in the lung microbial community influence idiopathic pulmonary fibrosis (IPF) progression. Whether the lung microbiome influences IPF host defense remains unknown. ⋯ These findings suggest that host-microbiome interactions influence PFS and fibroblast responsiveness.
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Am. J. Respir. Crit. Care Med. · Jul 2017
Randomized Controlled TrialPreventing Severe Asthma Exacerbations in Children: A Randomised Trial of Mite Impermeable Bedcovers.
Allergen exposure in sensitized individuals with asthma interacts with viruses to increase the risk of asthma exacerbation. ⋯ Mite-impermeable encasings are effective in reducing the number of mite-sensitized children with asthma attending the hospital with asthma exacerbations but not the number requiring oral prednisolone. This simple measure may reduce the health care burden of asthma exacerbations in children. Clinical trial registered with www.isrctn.com (ISRCTN 69543196).
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Am. J. Respir. Crit. Care Med. · Jul 2017
Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension.
Prognostication is important when counseling patients and defining treatment strategies in pulmonary arterial hypertension (PAH). ⋯ MRI measurements reflecting right ventricular structure and stiffness of the proximal pulmonary vasculature are independent predictors of outcome in PAH. In combination with clinical data MRI has moderate prognostic accuracy in the evaluation of patients with PAH.