American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Apr 2020
Quantitative Interferon Gamma Release Assay and Tuberculin Skin Test Results to Predict Incident Tuberculosis: A Prospective Cohort Study.
Rationale: Development of diagnostic tools with improved predictive value for tuberculosis (TB) is a global research priority. Objectives: We evaluated whether implementing higher diagnostic thresholds than currently recommended for QuantiFERON Gold-in-Tube (QFT-GIT), T-SPOT. TB, and the tuberculin skin test (TST) might improve prediction of incident TB. ⋯ Conclusions: Implementation of higher thresholds for QFT-GIT, T-SPOT. TB, and TST modestly increases positive predictive value for incident TB, but markedly reduces sensitivity. Novel biomarkers or validated multivariable risk algorithms are required to improve prediction of incident TB.